Quick Answer: How Does Pregnancy Affect Drug Metabolism?

How does pregnancy affect pharmacodynamics?

Physiologic changes in pregnancy induce profound alterations to the pharmacokinetic properties of many medications.

These changes affect distribution, absorption, metabolism, and excretion of drugs, and thus may impact their pharmacodynamic properties during pregnancy..

How does pregnancy affect volume of distribution?

Expanded extracellular volume and total body water will increase volume of distribution for hydrophilic drugs, leading to lower plasma concentrations. In addition, maternal body fat expands by approximately 4 kg, increasing the volume of distribution for lipophilic drugs.

Which painkiller is safe in pregnancy?

Paracetamol has been used routinely during all stages of pregnancy to reduce a high temperature and for pain relief. There’s no clear evidence it has any harmful effects on an unborn baby. But as with any medicine taken during pregnancy, use paracetamol at the lowest effective dose for the shortest possible time.

Does metabolism change after pregnancy?

For maternal metabolism, pregnancy ends not with birth, but with weaning. Data from animal models and human studies suggest that lactation is associated with favorable changes in adiposity, glycemic control, and lipid homeostasis that persist long after weaning.

Can I lose fat during pregnancy?

Fortunately, growing research suggests that losing some weight during pregnancy might be possible — and even beneficial — for some women who are extremely overweight or obese (have a BMI over 30). Losing weight, on the other hand, isn’t appropriate for pregnant women who were at a healthy weight before pregnancy.

How does pregnancy affect drug absorption?

Drug absorption is affected by slower gastric emptying and slower bowel and colonic transit time. The increased plasma volume, change in protein binding, and lower ratio of lean muscle to adipose tissue during pregnancy may result in a greater volume of drug distribution for lipophilic drugs.

Can a pregnant woman take drugs?

In general, drugs should not be used during pregnancy unless necessary because many can harm the fetus. About 2 to 3% of all birth defects result from drugs that are taken to treat a disorder or symptom. Sometimes drugs are essential for the health of the pregnant woman and the fetus.

Which medicine is harmful during pregnancy?

What medicines should you avoid during pregnancy?Bismuth subsalicylate (such as Pepto-Bismol).Phenylephrine or pseudoephedrine, which are decongestants. … Cough and cold medicines that contain guaifenesin. … Pain medicines like aspirin and ibuprofen (such as Advil and Motrin) and naproxen (such as Aleve).

Which drug has highest volume of distribution?

ExamplesDrugVDCommentsWarfarin8LReflects a high degree of plasma protein binding.Theophylline, Ethanol30LRepresents distribution in total body water.Chloroquine15000LShows highly lipophilic molecules which sequester into total body fat.NXY-0598LHighly charged hydrophilic molecule.

What is a high VD?

Definition/Introduction A drug with a high Vd has a propensity to leave the plasma and enter the extravascular compartments of the body, meaning that a higher dose of a drug is required to achieve a given plasma concentration. (High Vd -> More distribution to other tissue) … (Low Vd -> Less distribution to other tissue)

What organ is the primary site of metabolism of drugs?

Although many sites of metabolism and excretion exist, the chief organ of metabolism is the liver, while the organ primarily tasked with excretion is the kidney. Any significant dysfunction in either organ can result in accumulation of the drug or its metabolites in toxic concentrations.

How does body mass affect drug metabolism?

Obesity also has an effect on the gastric emptying and gut permeability, meaning that drugs are absorbed at different rates to normal. Drug penetration into tissue is also affected, meaning that a higher dose may be needed in order to reach effective concentrations.

Do you have a faster metabolism when pregnant?

The basal metabolic rate The amount of oxygen consumed is an index of the pregnant woman’s metabolism when she is at rest—her basal metabolism. The rate begins to rise during the third month of pregnancy and may double the normal rate (+10 percent) by the time of delivery.

How does pregnancy affect metabolism?

The body of a pregnant woman slowly increases its energy requirements to help fuel the changes and growth taking place in both the mother and baby. Metabolic rates increase substantially by just 15 weeks’ gestation and peak in the third trimester during the greatest growth phase.

What are drugs used in pregnancy?

Drugs are used in over half of all pregnancies, and prevalence of use is increasing. The most commonly used drugs include antiemetics, antacids, antihistamines, analgesics, antimicrobials, diuretics, hypnotics, tranquilizers, and social and illicit drugs.

What is a good volume of distribution?

If the volume is between 7 4 and 15 7 L, the drug is thought to be distributed throughout the blood (plasma and red blood cells). If the volume of distribution is larger than 42, the drug is thought to be distributed to all tissues in the body, especially the fatty tissue.

What can cross the placental barrier?

Whether a substance may pass through the placenta between mother and fetus depends on its molecular size, shape, and charge. … Other substances that pass through the placenta include red blood cell antigens, carbon dioxide, oxygen, some viruses, and nutrients.

What factors affect drug metabolism?

Physiological factors that can influence drug metabolism include age, individual variation (e.g., pharmacogenetics), enterohepatic circulation, nutrition, intestinal flora, or sex differences.